Our Research is published in Nature Chemistry!

The Rice lab of synthetic chemist László Kürti reported its success at creating highly efficient aminating and hydroxylating reagents from abundant and biorenewable terpenoids that promises to make the reagents' use environmentally friendly and cost-effective.

Read the abstract at http://dx.doi.org/10.1038/nchem.2672

News release can be found online at http://news.rice.edu/2016/11/28/pine-product-offers-fresh-take-on-fine-chemical-synthesis/

Our collaborative Science paper just went online!

Primary and N-alkyl arylamine motifs are key functional groups in pharmaceuticals, agrochemicals, and functional materials, as well as in bioactive natural products. However, there is a dearth of generally applicable methods for the direct replacement of aryl hydrogens with NH2/NH(alkyl) moieties. Here, we present a mild dirhodium-catalyzed C-H amination for conversion of structurally diverse monocyclic and fused aromatics to the corresponding primary and N-alkyl arylamines using NH2/NH(alkyl)-O-(sulfonyl)hydroxylamines as aminating agents; the relatively weak RSO2O-N bond functions as an internal oxidant. The methodology is operationally simple, scalable, and fast at or below ambient temperature, furnishing arylamines in moderate-to-good yields and with good regioselectivity. It can be readily extended to the synthesis of fused N-heterocycles. (Link to the article: DOI: 10.1126/science.aaf8713)

See press release here: http://news.rice.edu/2016/09/12/chemists-make-strides-to-simplify-drug-design-and-synthesis/